Further documentation is available here. IL-1beta aloe vera production chain pdf Nlrp3 inflammasome components.
P2X7 receptor expression is downregulated in Aloe-treated activated macrophages. LPS-induced activation of signaling pathways like NFkB, p38 and JNK is inhibited. However, its role on the IL-1β inflammatory cytokine production has not been studied. IL-1β production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. Nlrp3 inflammasome-mediated IL-1β production in LPS-activated human THP-1 cells and monocyte-derived macrophages.
IL-8, TNFα, IL-6 and IL-1β cytokine production in a dose dependent manner. The inhibitory effect was substantially more pronounced in the primary cells. IL-1β, Nlrp3, caspase-1 as well as that of the P2X7 receptor in the LPS-induced primary macrophages. These results may provide a new therapeutic approach to regulate inflammasome-mediated responses.
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