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Injection solutions should be free from foreign particles of varying types, but preparing injectable medicinal products that conform to a test for clarity is one of the biggest problems faced by a pharmaceutical manufacturer. Despite meticulous care at every stage of manufacture, the ampoules will often contain foreign matter. It follows that the final stage of manufacture is an inspection stage to satisfy the producer that the product has reached a predetermined standard of cleanliness. This chapter describes some of the inspection methods presently available, together with an evaluation of their advantages and drawbacks. It describes the detection of particulate contamination by means of a screen filtration pressure method. This article has not been cited.
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